2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  4. Casein Kinase

Casein Kinase

Casein Kinase

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Casein Kinases (CKs), a group of ubiquitous Ser/Thr kinases, regulate a wide range of cellular functions in eukaryotes, including phosphorylation of proteins that are substrates for degradation via the ubiquitin-proteasome system (UPS). Two casein kinases, casein kinase-1 (CK-1) and casein kinase-2 (CK-2), have been characterized from many sources.

CK1 kinases exist in at least seven isoforms (α, β, γ1-3, δ, and ɛ) in mammals and CK1 kinases phosphorylate various substrates to play vital roles in diverse physiological processes such as DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis. Casein kinase 2 (CK2) is a highly pleiotropic serine-threonine kinase, which catalyzed phosphorylation of more than 300 proteins that are implicated in regulation of many cellular functions, such as signal transduction, transcriptional control, apoptosis, and the cell cycle.

Casein Kinase Isoform Specific Products:

Casein Kinase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-171292
    CK1δ-IN-9
    		Inhibitor
    CK1δ-IN-9 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1δ with IC50 of 1.4 nM. CK1δ-IN-9 inhibits p38α and p38β with IC50 of 0.25 μM and 0.78 μM. CK1δ-IN-9 exhibits pharmacokinetic characteristics with a good oral bioavailability (70%) and a moderate clearance.
    CK1δ-IN-9
  • HY-148837
    PROTAC c-Myc degrader-1
    		Degrader
    PROTAC c-Myc degrader-1 (Compound A153) is a multiple target protein degrader (PROTAC). PROTAC c-Myc degrader-1 effective degrades c-MYC, CK1α, GSPT1 and IKZF1/2/3 proteins in a variety of tumor cells. PROTAC c-Myc degrader-1 can be used for c-Myc high expression related disease research, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection (Pink: c-Myc ligand (HY-168685); Blue: E3 ligase ligand (HY-W093472); Black: linker (HY-W015808)).
    PROTAC c-Myc degrader-1
  • HY-169719
    CK1δ-IN-6
    		Inhibitor
    CK1δ-IN-6 (Compound 303) is a Casein kinase 1δ inhibitor. CK1δ-IN-6 is promising for research of Alzheimer's disease.
    CK1δ-IN-6
  • HY-120036
    Tyrphostin AG1112
    		Inhibitor
    Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively.
    Tyrphostin AG1112
  • HY-103384
    TMCB
    		Inhibitor
    TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct Ki values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively.
    TMCB
  • HY-143461
    CK2 inhibitor 3
    		Inhibitor
    CK2 inhibitor 3 is a potent CK2 inhibitor with IC50 value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases.
    CK2 inhibitor 3
  • HY-171290
    Casein kinase 1δ-IN-31
    		Inhibitor
    Casein kinase 1δ-IN-31 (Compound 16) is the inhibitor for casein kinase (CK) that inhibits CK1α, CK1δ, and p38α with IC50s of 196, 17, and 18 nM, respectively. Casein kinase 1δ-IN-31 inhibits Double Homeobox 4 (DUX4) with IC50 of 1200 nM.
    Casein kinase 1δ-IN-31
  • HY-171300
    p38α inhibitor 8
    		Inhibitor
    p38α inhibitor 8 (Compound 1) exhibits inhibitory activity against p38α MAPK and CK1δ with IC50 of 0.21 µM and 0.202 µM[1]>.
    p38α inhibitor 8
  • HY-W042648
    4,5,6,7-Tetrabromo-1H-benzimidazole
    		Inhibitor
    4,5,6,7-Tetrabromobenzimidazole is a selective and ATP competitive CK2 (casein kinase 2) inhibitor.
    4,5,6,7-Tetrabromo-1H-benzimidazole
  • HY-171301
    p38α MAPK/CK1δ inhibitor-1
    		Inhibitor
    p38α MAPK/CK1δ inhibitor-1 (Compound 3) exhibits inhibitory activity against p38α MAPK and CK1δ with IC50s of 0.185 µM and 0.089 µM.
    p38α MAPK/CK1δ inhibitor-1
  • HY-168707
    CK2-IN-14
    		Inhibitor
    CK2-IN-14 (Compound 10b) is an inhibitor for cyclin kinase 2α with an IC50 of 36.7 nM. CK2-IN-14 inhibits the growth of cancer cell 786-O and U937 with GI50 of 7.3 μM and 7.5 μM.
    CK2-IN-14
  • HY-10108R
    LY294002 (Standard)
    		Inhibitor
    LY294002 (Standard) is the analytical standard of LY294002. This product is intended for research and analytical applications. LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4?μM. LY294002 is an apoptosis activator.
    LY294002 (Standard)
  • HY-160532
    CK1α degrader-1
    		Degrader
    CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC50 of 0.105 μM. CK1α degrader-1 can be used for the research of cancer.
    CK1α degrader-1
  • HY-169556
    CK1δ-IN-7
    		Inhibitor
    CK1δ-IN-7 (Compound 488) is the inhibitor for casein kinase 1δ (CK1δ).
    CK1δ-IN-7
  • HY-170782
    CZP-IN-1
    		Inhibitor
    CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi cruzipain (CZP) and does not inhibit cathepsin L (IC50=28 nM). CZP-IN-1 can be used for the research of Chagas disease.
    CZP-IN-1
  • HY-W840382
    CK1δ-IN-8
    		Inhibitor
    CK1δ-IN-8 (Compound 429) is a CK1δ inhibitor that can be used in Alzheimer's disease research.
    CK1δ-IN-8
  • HY-P4056
    CIGB-300
    		Antagonist
    CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase CK2. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research.
    CIGB-300
  • HY-50733
    CX-5011 free base
    		Inhibitor
    CX-5011 free base is a potent CK2 inhibitor. CX-5011 free base also is a Rac-1 activator. CX-5011 free base induces methuosis and promotes macropinocytosis. CX-5011 free base induces apoptosis. CX-5011 free base decreases the expression of rpS6 phosphorylation.
    CX-5011 free base
  • HY-P3234
    Ac-ESMD-CHO
    		Inhibitor
    Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site.
    Ac-ESMD-CHO
  • HY-10108AR
    LY294002 hydrochloride (Standard)
    		Inhibitor
    LY294002 (hydrochloride) (Standard) is the analytical standard of LY294002 (hydrochloride). This product is intended for research and analytical applications. LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC50 values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research[1][2][3].
    LY294002 hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Casein Kinase Isoform Comparison

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